Blar i forfatter "Agewall, Stefan"

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    • Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis 

      Nguyen, Thao; Hokstad, Ingrid; Fagerland, Morten; Mollnes, Tom Eirik; Hollan, Ivana; Feinberg, Mark W.; Hjeltnes, Gunnbjørg; Eilertsen, Gro Østli; Mikkelsen, Knut; Agewall, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)
      Background The complement system plays an important role in pathophysiology of cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid arthritis (RA). The role of complement activation in response to treatment, and in development of premature CVD in RA, is limited. Therefore, we examined the effects of methotrexate (MTX) and tumor necrosis factor inhibitors ...

    • Antirheumatic therapy is not associated with changes in circulating N-terminal pro-brain natriuretic peptide levels in patients with autoimmune arthritis 

      Nguyen, Thao H.P.; Fagerland, Morten; Deyab, Gia; Hjeltnes, Gunnbjørg; Hollan, Ivana; Feinberg, Mark W.; Eilertsen, Gro Østli; Mikkelsen, Knut; Agewall, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-25)
      Background: Patients with autoimmune arthritis (AA) are at increased risk for impaired cardiac function and heart failure. This may be partly due to the effect of inflammation in heart function. The impact of antirheumatic drugs on cardiac dysfunction in AA remains controversial. Therefore, we aimed to examine effects of antirheumatic treatment on serum N-terminal pro-brain natriuretic peptide ...

    • Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis 

      Deyab, Gia; Reine, Trine M.; Vuong, Tram Thu; Jenssen, Trond Geir; Hjeltnes, Gunnbjørg; Agewall, Stefan; Mikkelsen, Knut; Førre, Øystein; Fagerland, Morten; Kolset, Svein Olav; Hollan, Ivana (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-09)
      The endothelial glycocalyx (EG) is essential for proper function of the endothelium and for vascular integrity, but its role in premature atherogenesis in rheumatoid arthritis (RA) has not been studied yet. EG impairment can play a role in pathogenesis of vascular disease, and one of its characteristics is shedding of syndecan-1 from endothelial cells. Syndecan-1 shedding is mediated by matrix ...

    • Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium 

      Bahls, Martin; Lorenz, Matthias W.; Dörr, Marcus; Gao, Lu; Kitagawa, Kazuo; Tuomainen, Tomi-Pekka; Agewall, Stefan; Berenson, Gerald; Catapano, Alberico L.; Norata, Guiseppe D.; Bots, Michiel L.; van Gilst, Wiek; Asselbergs, Folkert W.; Brouwers, Frank P.; Uthoff, Heiko; Sander, Dirk; Poppert, Holger; Hecht Olsen, Michael; Empana, Jean Philippe; Schminke, Ulf; Baldassarre, Damiano; Veglia, Fabrizio; Franco, Oscar H.; Kavousi, Maryam; de Groot, Eric; Mathiesen, Ellisiv B.; Grigore, Liliana; Polak, Joseph F.; Rundek, Tatjana; Stehouwer, Coen D.A.; Skilton, Michael R.; Hatzitolios, Apostolos I.; Savopoulos, Christos; Ntaios, George; Plichart, Matthieu; McLachlan, Stela; Lind, Lars; Willeit, Peter; Steinmetz, Helmuth; Desvarieux, Moise; Ikram, M. Arfan; Johnsen, Stein Harald; Schmidt, Caroline; Willeit, Johann; Ducimetière, Pierre; Price, Jackie F.; Bergström, Göran; Kauhanen, Jussi; Kiechl, Stefan; Sitzer, Matthias; Bickel, Horst; Sacco, Ralph L.; Hofman, Albert; Völzke, Henry; Thompson, Simon G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)
      <i>Aims</i> - Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.<p> <p><i>Methods and results</i> - An individual participant meta-analysis was used to associate the annualised progression of systolic ...

    • Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study 

      Hokstad, Ingrid; Deyab, Gia; Fagerland, Morten; Lyberg, Torstein; Hjeltnes, Gunnbjørg; Førre, Øystein Thorleiv; Agewall, Stefan; Mollnes, Tom Eirik; Hollan, Ivana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      <i>Background</i> - The complement system is involved in pathogenesis of cardiovascular disease, and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, we examined complement activation in SpA, and its relationship to antirheumatic treatment, inflammatory and cardiovascular markers. <p> <p><i>Methods</i> - From PSARA, a prospective observational study, we examined ...